Assay Detail
Functional
CHEMBL1033262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RF in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.24 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138469 | 7,8-DIHYDROCALANOLIDE B | — | 1 | 7.00 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 6.70 |
| CHEMBL7187 | COSTATOLIDE | — | 1 | 6.70 |
| CHEMBL489967 | — | — | 1 | 6.58 |
| CHEMBL36985 | — | — | 1 | 6.30 |
| CHEMBL511557 | BUCHAPINE | — | 1 | 6.03 |
| CHEMBL444821 | — | — | 1 | 5.79 |
| CHEMBL8443 | NITIDINE CHLORIDE | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138469 | 7,8-DIHYDROCALANOLIDE B | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL7187 | COSTATOLIDE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL489967 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL36985 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL511557 | BUCHAPINE | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL444821 | — | EC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL8443 | NITIDINE CHLORIDE | EC50 | = | 14000.0 | nM | 4.85 |