Assay Detail
Functional
CHEMBL1033546
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Agonist activity at human cloned adrenergic beta-1 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.32 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.92 |
| CHEMBL561348 | — | — | 1 | 7.08 |
| CHEMBL561291 | — | — | 1 | 6.82 |
| CHEMBL551831 | — | — | 1 | 6.75 |
| CHEMBL563810 | — | — | 1 | 6.72 |
| CHEMBL561693 | — | — | 1 | 6.58 |
| CHEMBL551350 | — | — | 1 | 6.55 |
| CHEMBL562153 | — | — | 1 | 6.46 |
| CHEMBL551892 | — | — | 1 | 6.31 |
| CHEMBL539226 | — | — | 1 | 6.26 |
| CHEMBL552434 | — | — | 1 | 6.26 |
| CHEMBL551832 | — | — | 1 | 6.23 |
| CHEMBL564556 | — | — | 1 | 6.22 |
| CHEMBL550743 | — | — | 1 | 6.18 |
| CHEMBL561211 | — | — | 1 | 6.15 |
| CHEMBL564544 | — | — | 1 | 6.14 |
| CHEMBL550746 | — | — | 1 | 6.12 |
| CHEMBL561818 | — | — | 1 | 6.04 |
| CHEMBL557269 | — | — | 1 | 6.02 |
| CHEMBL417613 | — | — | 1 | 5.80 |
| CHEMBL552089 | — | — | 1 | 5.77 |
| CHEMBL466705 | — | — | 1 | 5.57 |
| CHEMBL552497 | — | — | 1 | 5.51 |
| CHEMBL562154 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL561348 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL561291 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL551831 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL563810 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL561693 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL551350 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL562153 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL551892 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL539226 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL552434 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL551832 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL564556 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL550743 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL561211 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL564544 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL550746 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL561818 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL557269 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL417613 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL552089 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL466705 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL552497 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL562154 | — | EC50 | > | 100000.0 | nM | - |