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Assay Detail

CHEMBL1033787

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Functional
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of viral replication after 5 days by MTT assay
ChEMBL ↗
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.
Sato M, Kawakami H, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito Y, Matsuzaki Y, Yamataka K, Ikeda S, Shinkai H.
J Med Chem (2009) 52 : 4869 -4882
PubMed 19719237 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 52 5.97 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL203443 — — 1 7.70
CHEMBL549549 — — 1 7.22
CHEMBL379664 — — 1 7.10
CHEMBL550893 — — 1 7.00
CHEMBL549546 — — 1 6.89
CHEMBL549611 — — 1 6.75
CHEMBL561099 — — 1 6.54
CHEMBL562360 — — 1 6.48
CHEMBL550895 — — 1 6.47
CHEMBL242883 — — 1 6.36
CHEMBL550691 — — 1 6.35
CHEMBL558286 — — 1 6.33
CHEMBL559903 — — 1 6.29
CHEMBL560439 — — 1 6.28
CHEMBL563162 — — 1 6.27
CHEMBL561437 — — 1 6.24
CHEMBL550220 — — 1 6.22
CHEMBL551437 — — 1 6.19
CHEMBL204656 ELVITEGRAVIR 4.0 1 6.05
CHEMBL565125 — — 1 5.89
CHEMBL550080 — — 1 5.89
CHEMBL558287 — — 1 5.78
CHEMBL549750 — — 1 5.70
CHEMBL551235 — — 1 5.69
CHEMBL561827 — — 1 5.63
CHEMBL560836 — — 1 5.55
CHEMBL560234 — — 1 5.47
CHEMBL561619 — — 1 5.14
CHEMBL206604 — — 1 5.12
CHEMBL563677 — — 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL203443 — EC50 = 20.0 nM 7.70
CHEMBL549549 — EC50 = 60.0 nM 7.22
CHEMBL379664 — EC50 = 80.0 nM 7.10
CHEMBL550893 — EC50 = 100.0 nM 7.00
CHEMBL549546 — EC50 = 130.0 nM 6.89
CHEMBL549611 — EC50 = 180.0 nM 6.75
CHEMBL561099 — EC50 = 290.0 nM 6.54
CHEMBL562360 — EC50 = 330.0 nM 6.48
CHEMBL550895 — EC50 = 340.0 nM 6.47
CHEMBL242883 — EC50 = 440.0 nM 6.36
CHEMBL550691 — EC50 = 450.0 nM 6.35
CHEMBL558286 — EC50 = 470.0 nM 6.33
CHEMBL559903 — EC50 = 510.0 nM 6.29
CHEMBL560439 — EC50 = 530.0 nM 6.28
CHEMBL563162 — EC50 = 540.0 nM 6.27
CHEMBL561437 — EC50 = 570.0 nM 6.24
CHEMBL550220 — EC50 = 600.0 nM 6.22
CHEMBL551437 — EC50 = 640.0 nM 6.19
CHEMBL204656 ELVITEGRAVIR EC50 = 900.0 nM 6.05
CHEMBL565125 — EC50 = 1300.0 nM 5.89
CHEMBL550080 — EC50 = 1300.0 nM 5.89
CHEMBL558287 — EC50 = 1680.0 nM 5.78
CHEMBL549750 — EC50 = 2000.0 nM 5.70
CHEMBL551235 — EC50 = 2040.0 nM 5.69
CHEMBL561827 — EC50 = 2340.0 nM 5.63
CHEMBL560836 — EC50 = 2800.0 nM 5.55
CHEMBL560234 — EC50 = 3400.0 nM 5.47
CHEMBL561619 — EC50 = 7300.0 nM 5.14
CHEMBL206604 — EC50 = 7500.0 nM 5.12
CHEMBL563677 — EC50 = 9800.0 nM 5.01
CHEMBL558481 — EC50 = 13590.0 nM 4.87
CHEMBL561423 — EC50 = 15900.0 nM 4.80
CHEMBL549816 — EC50 = 17100.0 nM 4.77
CHEMBL563525 — EC50 = 27700.0 nM 4.56
CHEMBL557891 — EC50 = 51600.0 nM 4.29
CHEMBL560960 — EC50 > 6000.0 nM -
CHEMBL537947 — EC50 > 6000.0 nM -
CHEMBL561100 — EC50 > 30000.0 nM -
CHEMBL554722 — EC50 = 115500.0 nM -
CHEMBL549404 — EC50 > 6000.0 nM -
CHEMBL549338 — EC50 > 6000.0 nM -
CHEMBL560761 — EC50 > 6000.0 nM -
CHEMBL560436 — EC50 > 30000.0 nM -
CHEMBL549405 — EC50 > 6000.0 nM -
CHEMBL381059 — EC50 > 30000.0 nM -
CHEMBL557480 — EC50 > 30000.0 nM -
CHEMBL408699 — EC50 = 108800.0 nM -
CHEMBL382680 — EC50 > 30000.0 nM -
CHEMBL560235 — EC50 > 30000.0 nM -
CHEMBL559705 — EC50 > 6000.0 nM -