Assay Detail
Binding
CHEMBL1034062
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant CCR5 expressed in human HeLa-P4 cells assessed as inhibition of human HeLa-P4 cells binding to HIV1 gp160 expressing CHO cells by cell-cell fusion assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.00 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460845 | — | — | 1 | 10.30 |
| CHEMBL457043 | — | — | 1 | 10.15 |
| CHEMBL461687 | — | — | 1 | 9.80 |
| CHEMBL256907 | MARAVIROC | 4.0 | 1 | 9.70 |
| CHEMBL459384 | — | — | 1 | 9.47 |
| CHEMBL456226 | — | — | 1 | 9.32 |
| CHEMBL461690 | — | — | 1 | 9.03 |
| CHEMBL457044 | — | — | 1 | 8.81 |
| CHEMBL469724 | — | — | 1 | 8.70 |
| CHEMBL457960 | — | — | 1 | 8.63 |
| CHEMBL461689 | — | — | 1 | 8.50 |
| CHEMBL459567 | — | — | 1 | 8.47 |
| CHEMBL518640 | — | — | 1 | 8.44 |
| CHEMBL458157 | — | — | 1 | 8.43 |
| CHEMBL460628 | — | — | 1 | 8.32 |
| CHEMBL518794 | — | — | 1 | 8.30 |
| CHEMBL459571 | — | — | 1 | 8.12 |
| CHEMBL514410 | — | — | 1 | 7.87 |
| CHEMBL456019 | — | — | 1 | 7.85 |
| CHEMBL456224 | — | — | 1 | 7.75 |
| CHEMBL459599 | — | — | 1 | 7.67 |
| CHEMBL460629 | — | — | 1 | 7.60 |
| CHEMBL459378 | — | — | 1 | 7.47 |
| CHEMBL469542 | — | — | 1 | 7.43 |
| CHEMBL460630 | — | — | 1 | 7.32 |
| CHEMBL518326 | — | — | 1 | 7.19 |
| CHEMBL460008 | — | — | 1 | 7.13 |
| CHEMBL459600 | — | — | 1 | 7.02 |
| CHEMBL460217 | — | — | 1 | 6.42 |
| CHEMBL459598 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460845 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL457043 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL461687 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL256907 | MARAVIROC | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL459384 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL456226 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL461690 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL457044 | — | IC50 | = | 1.54 | nM | 8.81 |
| CHEMBL469724 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL457960 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL461689 | — | IC50 | = | 3.16 | nM | 8.50 |
| CHEMBL459567 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL518640 | — | IC50 | = | 3.63 | nM | 8.44 |
| CHEMBL458157 | — | IC50 | = | 3.76 | nM | 8.43 |
| CHEMBL460628 | — | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL518794 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL459571 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL514410 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL456019 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL456224 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL459599 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL460629 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL459378 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL469542 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL460630 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL518326 | — | IC50 | = | 64.4 | nM | 7.19 |
| CHEMBL460008 | — | IC50 | = | 73.5 | nM | 7.13 |
| CHEMBL459600 | — | IC50 | = | 94.6 | nM | 7.02 |
| CHEMBL460217 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL459598 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL516939 | — | IC50 | = | 1849.0 | nM | 5.73 |
| CHEMBL460009 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL461688 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL515193 | — | IC50 | = | 0.003 | nM | - |
| CHEMBL456425 | — | IC50 | > | 25000.0 | nM | - |