Assay Detail
Binding
CHEMBL1034432
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Inhibition of WNV NS2B-NS3 protease by enzymatic assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | West Nile virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.01 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177281 | AMICARBALIDE | 2.0 | 1 | 5.55 |
| CHEMBL550687 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177281 | AMICARBALIDE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL550687 | — | IC50 | = | 34200.0 | nM | 4.47 |