Assay Detail
Binding
CHEMBL1034436
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Binding affinity to WNV NS2B(K96A)-NS3 protease measured as change of 15N chemical shift of Ser137 by NMR spectroscopy
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | West Nile virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flaviviral protease inhibitors identified by fragment-based library docking into a structure generated by molecular dynamics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 4.05 | 4.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177281 | AMICARBALIDE | 2.0 | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177281 | AMICARBALIDE | Kd | = | 90000.0 | nM | 4.05 |