Assay Detail
Functional
CHEMBL1034995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.31 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494709 | — | — | 1 | 6.51 |
| CHEMBL492480 | — | — | 1 | 6.31 |
| CHEMBL522691 | — | — | 1 | 6.22 |
| CHEMBL18840 | — | — | 1 | 6.20 |
| CHEMBL492871 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494709 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL492480 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL522691 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL18840 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL492871 | — | EC50 | = | 4500000.0 | nM | - |