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Assay Detail

CHEMBL1035202

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tissue factor/factor 7a
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Coagulation factor VII/tissue factor (CHEMBL2095194) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
Kotian PL, Krishnan R, Rowland S, El-Kattan Y, Saini SK, Upshaw R, Bantia S, Arnold S, Babu YS, Chand P.
Bioorg Med Chem (2009) 17 : 3934 -3958
PubMed 19409795 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 10.17 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL505190 — — 1 11.00
CHEMBL505189 — — 1 11.00
CHEMBL484616 — — 1 10.96
CHEMBL506771 — — 1 10.96
CHEMBL526504 — — 1 10.96
CHEMBL523251 — — 1 10.92
CHEMBL520364 — — 1 10.89
CHEMBL506772 — — 1 10.85
CHEMBL524370 — — 1 10.70
CHEMBL524732 — — 1 10.68
CHEMBL503584 — — 1 10.62
CHEMBL487956 — — 1 10.60
CHEMBL507281 — — 1 10.54
CHEMBL488778 — — 1 10.52
CHEMBL507020 — — 1 10.48
CHEMBL484615 — — 1 10.47
CHEMBL499632 — — 1 10.44
CHEMBL487955 — — 1 10.38
CHEMBL505720 — — 1 10.35
CHEMBL497067 — — 1 10.28
CHEMBL498047 — — 1 10.22
CHEMBL519886 — — 1 10.17
CHEMBL527118 — — 1 10.12
CHEMBL500948 — — 1 10.04
CHEMBL485705 — — 1 10.01
CHEMBL525274 — — 1 10.01
CHEMBL524548 — — 1 9.98
CHEMBL224485 — — 1 9.92
CHEMBL526193 — — 1 9.89
CHEMBL499829 — — 1 9.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL505190 — IC50 = 0.01 nM 11.00
CHEMBL505189 — IC50 = 0.01 nM 11.00
CHEMBL506771 — IC50 = 0.011 nM 10.96
CHEMBL526504 — IC50 = 0.011 nM 10.96
CHEMBL484616 — IC50 = 0.011 nM 10.96
CHEMBL523251 — IC50 = 0.012 nM 10.92
CHEMBL520364 — IC50 = 0.013 nM 10.89
CHEMBL506772 — IC50 = 0.014 nM 10.85
CHEMBL524370 — IC50 = 0.02 nM 10.70
CHEMBL524732 — IC50 = 0.021 nM 10.68
CHEMBL503584 — IC50 = 0.024 nM 10.62
CHEMBL487956 — IC50 = 0.025 nM 10.60
CHEMBL507281 — IC50 = 0.029 nM 10.54
CHEMBL488778 — IC50 = 0.03 nM 10.52
CHEMBL507020 — IC50 = 0.033 nM 10.48
CHEMBL484615 — IC50 = 0.034 nM 10.47
CHEMBL499632 — IC50 = 0.036 nM 10.44
CHEMBL487955 — IC50 = 0.042 nM 10.38
CHEMBL505720 — IC50 = 0.045 nM 10.35
CHEMBL497067 — IC50 = 0.052 nM 10.28
CHEMBL498047 — IC50 = 0.06 nM 10.22
CHEMBL519886 — IC50 = 0.067 nM 10.17
CHEMBL527118 — IC50 = 0.076 nM 10.12
CHEMBL500948 — IC50 = 0.092 nM 10.04
CHEMBL485705 — IC50 = 0.097 nM 10.01
CHEMBL525274 — IC50 = 0.098 nM 10.01
CHEMBL524548 — IC50 = 0.104 nM 9.98
CHEMBL224485 — IC50 = 0.12 nM 9.92
CHEMBL526193 — IC50 = 0.13 nM 9.89
CHEMBL499829 — IC50 = 0.19 nM 9.72
CHEMBL504391 — IC50 = 0.231 nM 9.64
CHEMBL502557 — IC50 = 0.32 nM 9.49
CHEMBL502292 — IC50 = 0.33 nM 9.48
CHEMBL501749 — IC50 = 0.5 nM 9.30
CHEMBL504657 — IC50 = 0.546 nM 9.26
CHEMBL501218 — IC50 = 0.65 nM 9.19
CHEMBL500947 — IC50 = 0.926 nM 9.03
CHEMBL498726 — IC50 = 1.22 nM 8.91
CHEMBL498545 — IC50 = 1.61 nM 8.79
CHEMBL451066 — IC50 = 0.009 nM -
CHEMBL502293 — IC50 = 0.009 nM -
CHEMBL505455 — IC50 = 0.009 nM -
CHEMBL486112 — IC50 = 0.009 nM -
CHEMBL485704 — IC50 = 0.009 nM -
CHEMBL507279 — IC50 = 0.008 nM -