Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1035204

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of factor 10a
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Coagulation factor X (CHEMBL244) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
Kotian PL, Krishnan R, Rowland S, El-Kattan Y, Saini SK, Upshaw R, Bantia S, Arnold S, Babu YS, Chand P.
Bioorg Med Chem (2009) 17 : 3934 -3958
PubMed 19409795 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 8.80 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL507020 — — 1 11.00
CHEMBL507279 — — 1 10.70
CHEMBL505190 — — 1 10.40
CHEMBL506772 — — 1 10.30
CHEMBL527118 — — 1 10.30
CHEMBL451066 — — 1 10.30
CHEMBL506771 — — 1 9.92
CHEMBL502293 — — 1 9.89
CHEMBL505189 — — 1 9.82
CHEMBL503584 — — 1 9.82
CHEMBL524548 — — 1 9.64
CHEMBL524370 — — 1 9.64
CHEMBL526193 — — 1 9.51
CHEMBL525274 — — 1 9.46
CHEMBL499632 — — 1 9.35
CHEMBL502292 — — 1 9.19
CHEMBL520364 — — 1 8.93
CHEMBL505455 — — 1 8.89
CHEMBL486112 — — 1 8.82
CHEMBL485704 — — 1 8.78
CHEMBL524732 — — 1 8.76
CHEMBL487955 — — 1 8.72
CHEMBL484615 — — 1 8.28
CHEMBL488778 — — 1 8.18
CHEMBL497067 — — 1 8.18
CHEMBL523251 — — 1 8.15
CHEMBL484616 — — 1 8.12
CHEMBL487956 — — 1 8.09
CHEMBL526504 — — 1 8.09
CHEMBL507281 — — 1 7.95

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL507020 — IC50 = 0.01 nM 11.00
CHEMBL507279 — IC50 = 0.02 nM 10.70
CHEMBL505190 — IC50 = 0.04 nM 10.40
CHEMBL506772 — IC50 = 0.05 nM 10.30
CHEMBL527118 — IC50 = 0.05 nM 10.30
CHEMBL451066 — IC50 = 0.05 nM 10.30
CHEMBL506771 — IC50 = 0.12 nM 9.92
CHEMBL502293 — IC50 = 0.13 nM 9.89
CHEMBL505189 — IC50 = 0.15 nM 9.82
CHEMBL503584 — IC50 = 0.15 nM 9.82
CHEMBL524548 — IC50 = 0.23 nM 9.64
CHEMBL524370 — IC50 = 0.23 nM 9.64
CHEMBL526193 — IC50 = 0.31 nM 9.51
CHEMBL525274 — IC50 = 0.35 nM 9.46
CHEMBL499632 — IC50 = 0.45 nM 9.35
CHEMBL502292 — IC50 = 0.64 nM 9.19
CHEMBL520364 — IC50 = 1.17 nM 8.93
CHEMBL505455 — IC50 = 1.3 nM 8.89
CHEMBL486112 — IC50 = 1.5 nM 8.82
CHEMBL485704 — IC50 = 1.65 nM 8.78
CHEMBL524732 — IC50 = 1.75 nM 8.76
CHEMBL487955 — IC50 = 1.9 nM 8.72
CHEMBL484615 — IC50 = 5.22 nM 8.28
CHEMBL497067 — IC50 = 6.62 nM 8.18
CHEMBL488778 — IC50 = 6.63 nM 8.18
CHEMBL523251 — IC50 = 7.1 nM 8.15
CHEMBL484616 — IC50 = 7.6 nM 8.12
CHEMBL487956 — IC50 = 8.14 nM 8.09
CHEMBL526504 — IC50 = 8.15 nM 8.09
CHEMBL507281 — IC50 = 11.27 nM 7.95
CHEMBL504391 — IC50 = 19.41 nM 7.71
CHEMBL505720 — IC50 = 26.96 nM 7.57
CHEMBL504657 — IC50 = 36.49 nM 7.44
CHEMBL500948 — IC50 = 46.05 nM 7.34
CHEMBL519886 — IC50 = 50.0 nM 7.30
CHEMBL485705 — IC50 = 50.0 nM 7.30
CHEMBL498545 — IC50 = 50.0 nM 7.30
CHEMBL501749 — IC50 = 59.0 nM 7.23
CHEMBL224485 — IC50 = 103.0 nM 6.99
CHEMBL502557 — IC50 - — -
CHEMBL500947 — IC50 - — -
CHEMBL498047 — IC50 - — -
CHEMBL498726 — IC50 - — -
CHEMBL499829 — IC50 - — -
CHEMBL501218 — IC50 - — -