Assay Detail
Binding
CHEMBL1035255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MRP1-mediated transport of [3H]LTC4 expressed in human HeLa T5 cells by liquid scintillation counting
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: synthesis, biological evaluation, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.93 | 6.10 |
| Ki | 1 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15177 | MK-571 | — | 1 | 6.22 |
| CHEMBL116734 | — | — | 1 | 6.10 |
| CHEMBL172119 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15177 | MK-571 | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL116734 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL172119 | — | IC50 | = | 1800.0 | nM | 5.75 |