Assay Detail
Binding
CHEMBL1035637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine mitochondrial MAOB
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.23 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472902 | — | — | 1 | 6.82 |
| CHEMBL472918 | — | — | 1 | 6.82 |
| CHEMBL474940 | — | — | 1 | 6.70 |
| CHEMBL489085 | — | — | 1 | 6.07 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 6.00 |
| CHEMBL472904 | — | — | 1 | 5.95 |
| CHEMBL515237 | — | — | 1 | 5.94 |
| CHEMBL515389 | — | — | 1 | 5.89 |
| CHEMBL474939 | — | — | 1 | 5.87 |
| CHEMBL474738 | — | — | 1 | 5.79 |
| CHEMBL514151 | — | — | 1 | 5.79 |
| CHEMBL523765 | — | — | 1 | 5.62 |
| CHEMBL472903 | — | — | 1 | 5.35 |
| CHEMBL508959 | — | — | 1 | 5.20 |
| CHEMBL514139 | — | — | 1 | 5.00 |
| CHEMBL472716 | — | — | 1 | 5.00 |
| CHEMBL447022 | — | — | 1 | 5.00 |
| CHEMBL489086 | — | — | 1 | 5.00 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 4.82 |
| CHEMBL489084 | — | — | 1 | 4.60 |
| CHEMBL515250 | — | — | 1 | 4.00 |
| CHEMBL508175 | — | — | 1 | 4.00 |
| CHEMBL473309 | — | — | 1 | 4.00 |
| CHEMBL505492 | — | — | 1 | 4.00 |
| CHEMBL472713 | — | — | 1 | 4.00 |
| CHEMBL472712 | — | — | 1 | 4.00 |
| CHEMBL514297 | — | — | 1 | 4.00 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472902 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL472918 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL474940 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL489085 | — | IC50 | = | 851.14 | nM | 6.07 |
| CHEMBL972 | SELEGILINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL472904 | — | IC50 | = | 1122.02 | nM | 5.95 |
| CHEMBL515237 | — | IC50 | = | 1148.15 | nM | 5.94 |
| CHEMBL515389 | — | IC50 | = | 1288.25 | nM | 5.89 |
| CHEMBL474939 | — | IC50 | = | 1348.96 | nM | 5.87 |
| CHEMBL474738 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL514151 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL523765 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL472903 | — | IC50 | = | 4466.84 | nM | 5.35 |
| CHEMBL508959 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL514139 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL472716 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL447022 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL489086 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL18116 | TOLOXATONE | IC50 | = | 15135.61 | nM | 4.82 |
| CHEMBL489084 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL515250 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL508175 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL473309 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL505492 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL472713 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL472712 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL514297 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 10000000.0 | nM | - |