Assay Detail
Binding
CHEMBL1035784
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Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylation
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 9.24 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495118 | — | — | 1 | 9.70 |
| CHEMBL522689 | — | — | 1 | 9.70 |
| CHEMBL495493 | — | — | 1 | 9.52 |
| CHEMBL493496 | — | — | 1 | 9.52 |
| CHEMBL494916 | — | — | 1 | 9.52 |
| CHEMBL523374 | — | — | 1 | 9.40 |
| CHEMBL523516 | — | — | 1 | 9.40 |
| CHEMBL494917 | — | — | 1 | 9.40 |
| CHEMBL495084 | — | — | 1 | 9.40 |
| CHEMBL495492 | — | — | 1 | 9.30 |
| CHEMBL494305 | — | — | 1 | 9.30 |
| CHEMBL521860 | — | — | 1 | 9.22 |
| CHEMBL522877 | — | — | 1 | 9.15 |
| CHEMBL495290 | — | — | 1 | 9.10 |
| CHEMBL492661 | — | — | 1 | 8.96 |
| CHEMBL524054 | — | — | 1 | 8.70 |
| CHEMBL493707 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495118 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL522689 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL495493 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL493496 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL494916 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL523374 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL523516 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL494917 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL495084 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL495492 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL494305 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL521860 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL522877 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL495290 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL492661 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL524054 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL493707 | — | Ki | = | 16.0 | nM | 7.80 |