Assay Detail
Binding
CHEMBL1035818
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Cdc7/Dbf4 by IMAP assay
32
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) (CHEMBL2111377) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.65 | 8.30 |
| Ki | 16 | 7.65 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505372 | — | — | 2 | 9.30 |
| CHEMBL444981 | — | — | 2 | 9.00 |
| CHEMBL463118 | — | — | 2 | 8.70 |
| CHEMBL463119 | — | — | 2 | 8.70 |
| CHEMBL510238 | — | — | 2 | 8.52 |
| CHEMBL449600 | — | — | 2 | 8.40 |
| CHEMBL463117 | — | — | 2 | 8.30 |
| CHEMBL504950 | — | — | 2 | 7.40 |
| CHEMBL463318 | — | — | 2 | 6.70 |
| CHEMBL507785 | — | — | 2 | 6.40 |
| CHEMBL507635 | — | — | 2 | 6.05 |
| CHEMBL512769 | — | — | 2 | 6.00 |
| CHEMBL457313 | — | — | 2 | 5.92 |
| CHEMBL457314 | — | — | 2 | - |
| CHEMBL513086 | — | — | 2 | - |
| CHEMBL459059 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505372 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL444981 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL463119 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL463118 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL510238 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL449600 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL505372 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL463117 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL444981 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL463119 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL463118 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL510238 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL449600 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL504950 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL463117 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL463318 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL507785 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL504950 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL507635 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL512769 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL457313 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL463318 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL507785 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL507635 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL512769 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL457313 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL459059 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL513086 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL457314 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL457314 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL513086 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL459059 | — | Ki | > | 3000.0 | nM | - |