Assay Detail
Functional
CHEMBL1035950
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Growth inhibition of human CEM cells after 3 days
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.85 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.61 |
| CHEMBL237950 | — | — | 1 | 5.28 |
| CHEMBL497740 | — | — | 1 | 5.23 |
| CHEMBL511882 | — | — | 1 | 5.00 |
| CHEMBL463791 | — | — | 1 | 4.94 |
| CHEMBL463790 | — | — | 1 | 4.81 |
| CHEMBL498090 | — | — | 1 | 4.80 |
| CHEMBL517159 | — | — | 1 | 4.80 |
| CHEMBL497057 | — | — | 1 | 4.72 |
| CHEMBL498089 | — | — | 1 | 4.65 |
| CHEMBL497741 | — | — | 1 | 4.56 |
| CHEMBL237949 | — | — | 1 | 4.55 |
| CHEMBL475335 | MEQUINDOX | — | 1 | 4.06 |
| CHEMBL463792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL237950 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL497740 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL511882 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL463791 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL463790 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL498090 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL517159 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL497057 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL498089 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL497741 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL237949 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL475335 | MEQUINDOX | IC50 | = | 87400.0 | nM | 4.06 |
| CHEMBL463792 | — | IC50 | = | 164000.0 | nM | - |