Assay Detail
Binding
CHEMBL1036409
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Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA (cytosine-5)-methyltransferase 3B (CHEMBL6095) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.52 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552309 | — | — | 1 | 6.52 |
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | — | 1 | 6.52 |
| CHEMBL555352 | — | — | 1 | 6.22 |
| CHEMBL560105 | — | — | 1 | 6.22 |
| CHEMBL560505 | — | — | 1 | 6.05 |
| CHEMBL560045 | — | — | 1 | 6.00 |
| CHEMBL556265 | — | — | 1 | 6.00 |
| CHEMBL563024 | — | — | 1 | 5.70 |
| CHEMBL549412 | — | — | 1 | 5.70 |
| CHEMBL552246 | — | — | 1 | 5.52 |
| CHEMBL560306 | — | — | 1 | 5.44 |
| CHEMBL561047 | — | — | 1 | 5.17 |
| CHEMBL538692 | — | — | 1 | 5.17 |
| CHEMBL563570 | — | — | 1 | 4.55 |
| CHEMBL552763 | — | — | 1 | 4.54 |
| CHEMBL563946 | — | — | 1 | 4.35 |
| CHEMBL564768 | — | — | 1 | 4.24 |
| CHEMBL558406 | — | — | 1 | - |
| CHEMBL558882 | — | — | 1 | - |
| CHEMBL559715 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552309 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL555352 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL560105 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL560505 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL560045 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL556265 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL563024 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL549412 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL552246 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL560306 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL561047 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL538692 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL563570 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL552763 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL563946 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL564768 | — | IC50 | = | 57200.0 | nM | 4.24 |
| CHEMBL558406 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL558882 | — | IC50 | = | 256000.0 | nM | - |
| CHEMBL559715 | — | IC50 | > | 1000000.0 | nM | - |