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Assay Detail

CHEMBL1036413

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CGS21680 from human adenosine A1 receptor
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Adenosine receptor A1 (CHEMBL226)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.
Gillespie RJ, Bamford SJ, Gaur S, Jordan AM, Lerpiniere J, Mansell HL, Stratton GC.
Bioorg Med Chem Lett (2009) 19 : 2664 -2667
PubMed 19362836 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 6.79 7.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL554623 1 7.91
CHEMBL556083 1 7.46
CHEMBL553449 1 7.42
CHEMBL550636 1 7.41
CHEMBL564473 1 7.38
CHEMBL549477 1 7.33
CHEMBL557084 1 7.27
CHEMBL538629 1 7.24
CHEMBL551368 1 7.14
CHEMBL560904 1 7.14
CHEMBL552511 1 7.10
CHEMBL557696 1 6.99
CHEMBL571672 1 6.91
CHEMBL549885 1 6.91
CHEMBL551373 1 6.88
CHEMBL561244 1 6.85
CHEMBL561645 1 6.80
CHEMBL558291 1 6.67
CHEMBL538949 1 6.58
CHEMBL561163 1 6.53
CHEMBL562421 1 6.51
CHEMBL563034 1 6.11
CHEMBL564224 1 6.05
CHEMBL564142 1 5.87
CHEMBL540156 1 5.70
CHEMBL557624 1 5.69
CHEMBL551177 1 5.45

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL554623 Ki = 12.2 nM 7.91
CHEMBL556083 Ki = 34.5 nM 7.46
CHEMBL553449 Ki = 38.0 nM 7.42
CHEMBL550636 Ki = 39.0 nM 7.41
CHEMBL564473 Ki = 42.0 nM 7.38
CHEMBL549477 Ki = 47.0 nM 7.33
CHEMBL557084 Ki = 54.0 nM 7.27
CHEMBL538629 Ki = 58.0 nM 7.24
CHEMBL551368 Ki = 73.0 nM 7.14
CHEMBL560904 Ki = 72.0 nM 7.14
CHEMBL552511 Ki = 80.0 nM 7.10
CHEMBL557696 Ki = 102.0 nM 6.99
CHEMBL571672 Ki = 124.0 nM 6.91
CHEMBL549885 Ki = 122.0 nM 6.91
CHEMBL551373 Ki = 131.0 nM 6.88
CHEMBL561244 Ki = 140.0 nM 6.85
CHEMBL561645 Ki = 157.0 nM 6.80
CHEMBL558291 Ki = 214.0 nM 6.67
CHEMBL538949 Ki = 260.0 nM 6.58
CHEMBL561163 Ki = 298.0 nM 6.53
CHEMBL562421 Ki = 311.0 nM 6.51
CHEMBL563034 Ki = 770.0 nM 6.11
CHEMBL564224 Ki = 884.0 nM 6.05
CHEMBL564142 Ki = 1342.0 nM 5.87
CHEMBL540156 Ki = 2004.0 nM 5.70
CHEMBL557624 Ki = 2062.0 nM 5.69
CHEMBL551177 Ki = 3540.0 nM 5.45