Assay Detail
Binding
CHEMBL1036431
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Inhibition of PTP1B
13
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.31 | 6.06 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551842 | LOBARIC ACID | — | 2 | 6.06 |
| CHEMBL558886 | — | — | 2 | 5.61 |
| CHEMBL559457 | — | — | 1 | 5.52 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.51 |
| CHEMBL550291 | — | — | 2 | 5.16 |
| CHEMBL562970 | — | — | 1 | 5.13 |
| CHEMBL173395 | ATRANORIN | — | 1 | 4.20 |
| CHEMBL454431 | METHYL ORSELLINATE | — | 1 | - |
| CHEMBL470649 | METHYL HAEMATOMMATE | — | 1 | - |
| CHEMBL505640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551842 | LOBARIC ACID | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL558886 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL559457 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL550291 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL562970 | — | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL173395 | ATRANORIN | IC50 | = | 63500.0 | nM | 4.20 |
| CHEMBL454431 | METHYL ORSELLINATE | IC50 | > | 200000.0 | nM | - |
| CHEMBL470649 | METHYL HAEMATOMMATE | IC50 | > | 200000.0 | nM | - |
| CHEMBL505640 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL551842 | LOBARIC ACID | Activity | - | — | - | |
| CHEMBL550291 | — | Activity | - | — | - | |
| CHEMBL558886 | — | Activity | - | — | - |