Assay Detail
Binding
CHEMBL1036447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DNMT3b2 at 45 uM
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA (cytosine-5)-methyltransferase 3B (CHEMBL6095) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 6 | - | - |
| IC50 | 1 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555352 | — | — | 1 | 6.22 |
| CHEMBL563803 | — | — | 1 | - |
| CHEMBL551578 | — | — | 1 | - |
| CHEMBL551499 | — | — | 1 | - |
| CHEMBL559710 | — | — | 2 | - |
| CHEMBL564490 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555352 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL563803 | — | Inhibition | = | 42.0 | % | - |
| CHEMBL551578 | — | Inhibition | = | 50.0 | % | - |
| CHEMBL551499 | — | Inhibition | = | 51.0 | % | - |
| CHEMBL559710 | — | Inhibition | = | - | % | - |
| CHEMBL559710 | — | Inhibition | = | 16.0 | % | - |
| CHEMBL564490 | — | Inhibition | = | 32.0 | % | - |