Assay Detail
Functional
CHEMBL1036455
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Cytotoxicity against human HCT116 cells by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.78 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557892 | — | — | 1 | 7.30 |
| CHEMBL571668 | — | — | 1 | 7.16 |
| CHEMBL539380 | — | — | 1 | 6.85 |
| CHEMBL561629 | — | — | 1 | 5.80 |
| CHEMBL570069 | — | — | 1 | - |
| CHEMBL562621 | — | — | 1 | - |
| CHEMBL550349 | — | — | 1 | - |
| CHEMBL561765 | — | — | 1 | - |
| CHEMBL564802 | — | — | 1 | - |
| CHEMBL560501 | — | — | 1 | - |
| CHEMBL550284 | — | — | 1 | - |
| CHEMBL563850 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557892 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL571668 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL539380 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL561629 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL570069 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL562621 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL550349 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL561765 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL564802 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL560501 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL550284 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL563850 | — | IC50 | > | 10000.0 | nM | - |