Assay Detail
Binding
CHEMBL1036571
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Inhibition of Pneumocystis carinii OSC expressed in Saccharomyces cerevisiae SMY8
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.30 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516750 | — | — | 1 | 7.30 |
| CHEMBL481608 | — | — | 1 | 7.30 |
| CHEMBL479464 | — | — | 1 | 7.30 |
| CHEMBL480049 | — | — | 1 | 7.16 |
| CHEMBL481199 | — | — | 1 | 6.92 |
| CHEMBL479653 | — | — | 1 | 6.70 |
| CHEMBL516921 | — | — | 1 | 6.70 |
| CHEMBL112210 | — | — | 1 | 6.64 |
| CHEMBL324162 | — | — | 1 | 6.47 |
| CHEMBL448434 | — | — | 1 | 6.47 |
| CHEMBL481015 | — | — | 1 | 6.40 |
| CHEMBL112553 | — | — | 1 | 6.26 |
| CHEMBL481200 | — | — | 1 | 6.22 |
| CHEMBL481622 | — | — | 1 | 6.10 |
| CHEMBL519122 | — | — | 1 | 6.00 |
| CHEMBL481209 | — | — | 1 | 6.00 |
| CHEMBL481811 | — | — | 1 | 5.92 |
| CHEMBL520926 | — | — | 1 | 5.89 |
| CHEMBL520270 | — | — | 1 | 5.65 |
| CHEMBL480259 | — | — | 1 | 5.60 |
| CHEMBL473035 | — | — | 1 | 5.52 |
| CHEMBL516767 | — | — | 1 | 4.00 |
| CHEMBL115497 | — | — | 1 | - |
| CHEMBL417571 | — | — | 1 | - |
| CHEMBL481208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516750 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL481608 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL479464 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL480049 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL481199 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL479653 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL516921 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL112210 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL324162 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL448434 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL481015 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL112553 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL481200 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL481622 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL519122 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL481209 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL481811 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL520926 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL520270 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL480259 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL473035 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL516767 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL115497 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL417571 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL481208 | — | IC50 | > | 100000.0 | nM | - |