Assay Detail
Functional
CHEMBL1036588
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Inhibition of fat accumulation in mouse 3T3L1 cells assessed as liberated triglyceride after 7 days
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 3T3-L1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: recognition of the importance of each amino acid residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.10 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453757 | — | — | 1 | 7.80 |
| CHEMBL394301 | TERNATIN (PEPTIDE) | — | 1 | 7.57 |
| CHEMBL509287 | — | — | 1 | 6.92 |
| CHEMBL510135 | — | — | 1 | 6.42 |
| CHEMBL454243 | — | — | 1 | 5.96 |
| CHEMBL446952 | — | — | 1 | 5.80 |
| CHEMBL447873 | — | — | 1 | 5.23 |
| CHEMBL502903 | — | — | 1 | 4.85 |
| CHEMBL443688 | — | — | 1 | 4.34 |
| CHEMBL451314 | — | — | 1 | - |
| CHEMBL451306 | — | — | 1 | - |
| CHEMBL510129 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453757 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL394301 | TERNATIN (PEPTIDE) | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL509287 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL510135 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL454243 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL446952 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL447873 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL502903 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL443688 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL451314 | — | IC50 | > | 130000.0 | nM | - |
| CHEMBL451306 | — | IC50 | > | 130000.0 | nM | - |
| CHEMBL510129 | — | IC50 | > | 130000.0 | nM | - |