Compound Detail
CHEMBL394301
TERNATIN (PEPTIDE) Enter ChEMBL ID:
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CC[C@H](C)[C@H]1NC(=O)[C@@H]([C@H](O)C(C)C)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)N(C)C1=O
Basic Information
| ChEMBL ID | CHEMBL394301 |
| Name | TERNATIN (PEPTIDE) |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | ZMFVAIFXJWEOMH-PTPSPKLBSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
738.0
MW (Da)
0.98
ALogP
8
HBA
4
HBD
188.8
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3T3-L1 CHEMBL614510 | IC50 | 7.57 | 7.06 | 27.0 | 6 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3T3-L1 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of fat accumulation in mouse 3T3L1 cells after 7 days | 19022665 |
| 3T3-L1 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of fat accumulation in mouse 3T3L1 cells assessed as liberated trigly... | 18798610 |
| 3T3-L1 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of fat-accumulation in mouse 3T3L1 cells | 19097891 |
| 3T3-L1 | IC50 | = | 280.0 | nM | 6.55 | Cytotoxicity against mouse 3T3L1 cells | 19022665 |
| 3T3-L1 | IC50 | = | 280.0 | nM | 6.55 | Toxicity in mouse 3T3L1 cells | 18798610 |
| 3T3-L1 | IC50 | = | 280.0 | nM | 6.55 | Cytotoxicity against mouse 3T3L1 cells | 19097891 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17590333 | 10.1016/j.bmcl.2007.06.015 | Mus musculus | 6 |
| 19097891 | 10.1016/j.bmcl.2008.11.109 | 3T3-L1 | 3 |
| 19022665 | 10.1016/j.bmcl.2008.11.003 | 3T3-L1 | 2 |
| 18798610 | 10.1021/jm800741n | 3T3-L1 | 2 |
| 17590333 | 10.1016/j.bmcl.2007.06.015 | 3T3-L1 | 1 |
Data from ChEMBL 36 via Core Engine