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Assay Detail

CHEMBL1036591

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant PTP1B after 30 mins
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B.
Thuong PT, Lee CH, Dao TT, Nguyen PH, Kim WG, Lee SJ, Oh WK.
J Nat Prod (2008) 71 : 1775 -1778
PubMed 18798681 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.14 5.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL169 URSOLIC ACID 2.0 1 5.51
CHEMBL470029 OLEANONIC ACID 1 5.46
CHEMBL486986 POMOLIC ACID 1 5.41
CHEMBL426373 1 5.39
CHEMBL168 OLEANOLIC_ACID 1 5.12
CHEMBL494111 1 5.09
CHEMBL493908 ROTUNGENIC ACID 1 4.96
CHEMBL522373 1 4.89
CHEMBL399873 UVAOL 1 4.81
CHEMBL493893 SPATHODIC ACID 1 4.73
CHEMBL492675 1 -
CHEMBL492472 SCUTELLARIC ACID 1 -
CHEMBL493907 1 -
CHEMBL523209 BARBINERVIC ACID 1 -
CHEMBL492458 COUSSARIC ACID 1 -
CHEMBL492457 DIOSPYRIC ACID B 1 -
CHEMBL521997 DIOSPYRIC ACID A 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL169 URSOLIC ACID IC50 = 3100.0 nM 5.51
CHEMBL470029 OLEANONIC ACID IC50 = 3500.0 nM 5.46
CHEMBL486986 POMOLIC ACID IC50 = 3900.0 nM 5.41
CHEMBL426373 IC50 = 4100.0 nM 5.39
CHEMBL168 OLEANOLIC_ACID IC50 = 7600.0 nM 5.12
CHEMBL494111 IC50 = 8100.0 nM 5.09
CHEMBL493908 ROTUNGENIC ACID IC50 = 10900.0 nM 4.96
CHEMBL522373 IC50 = 12800.0 nM 4.89
CHEMBL399873 UVAOL IC50 = 15600.0 nM 4.81
CHEMBL493893 SPATHODIC ACID IC50 = 18800.0 nM 4.73
CHEMBL492675 IC50 > 30000.0 nM -
CHEMBL492472 SCUTELLARIC ACID IC50 > 30000.0 nM -
CHEMBL493907 IC50 > 30000.0 nM -
CHEMBL523209 BARBINERVIC ACID IC50 > 30000.0 nM -
CHEMBL492458 COUSSARIC ACID IC50 > 30000.0 nM -
CHEMBL492457 DIOSPYRIC ACID B IC50 > 30000.0 nM -
CHEMBL521997 DIOSPYRIC ACID A IC50 > 30000.0 nM -