Assay Detail
ADMET
CHEMBL1036671
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Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.67 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508828 | — | — | 1 | 5.28 |
| CHEMBL456899 | — | — | 1 | 5.24 |
| CHEMBL515509 | — | — | 1 | 4.66 |
| CHEMBL215692 | — | — | 1 | 4.66 |
| CHEMBL459062 | — | — | 1 | 4.59 |
| CHEMBL456688 | — | — | 1 | 4.19 |
| CHEMBL468965 | — | — | 1 | 4.05 |
| CHEMBL458213 | — | — | 1 | - |
| CHEMBL446515 | — | — | 1 | - |
| CHEMBL458215 | — | — | 1 | - |
| CHEMBL467401 | — | — | 1 | - |
| CHEMBL457986 | — | — | 1 | - |
| CHEMBL458214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508828 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL456899 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL515509 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL215692 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL459062 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL456688 | — | IC50 | = | 65100.0 | nM | 4.19 |
| CHEMBL468965 | — | IC50 | = | 89700.0 | nM | 4.05 |
| CHEMBL458213 | — | IC50 | = | 152000.0 | nM | - |
| CHEMBL446515 | — | IC50 | > | 135000.0 | nM | - |
| CHEMBL458215 | — | IC50 | > | 161000.0 | nM | - |
| CHEMBL467401 | — | IC50 | > | 169000.0 | nM | - |
| CHEMBL457986 | — | IC50 | > | 181000.0 | nM | - |
| CHEMBL458214 | — | IC50 | > | 181000.0 | nM | - |