Assay Detail
Binding
CHEMBL1036849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.49 | 10.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505175 | — | — | 1 | 10.46 |
| CHEMBL505420 | — | — | 1 | 10.40 |
| CHEMBL499209 | — | — | 1 | 9.42 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 9.37 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 9.16 |
| CHEMBL503762 | — | — | 1 | 8.45 |
| CHEMBL449143 | — | — | 1 | 7.69 |
| CHEMBL452372 | — | — | 1 | 7.10 |
| CHEMBL510205 | — | — | 1 | 6.44 |
| CHEMBL510728 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505175 | — | IC50 | = | 0.035 | nM | 10.46 |
| CHEMBL505420 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL499209 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL316446 | ENDOMORPHIN-1 | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL503762 | — | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL449143 | — | IC50 | = | 20.4 | nM | 7.69 |
| CHEMBL452372 | — | IC50 | = | 79.95 | nM | 7.10 |
| CHEMBL510205 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL510728 | — | IC50 | = | 400.6 | nM | 6.40 |