Assay Detail
Binding
CHEMBL1036967
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Inhibition of LIMK1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.60 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570126 | — | — | 1 | 9.30 |
| CHEMBL570116 | — | — | 1 | 8.49 |
| CHEMBL565452 | — | — | 1 | 8.43 |
| CHEMBL570820 | — | — | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570126 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL570116 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL565452 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL570820 | — | IC50 | = | 6.6 | nM | 8.18 |