Assay Detail
Functional
CHEMBL1036992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B bearing wild type protease infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by XTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.38 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573809 | — | — | 1 | 9.82 |
| CHEMBL573717 | — | — | 1 | 9.48 |
| CHEMBL573888 | — | — | 1 | 8.27 |
| CHEMBL573887 | — | — | 1 | 6.85 |
| CHEMBL573845 | — | — | 1 | 6.77 |
| CHEMBL573789 | — | — | 1 | 6.60 |
| CHEMBL573868 | — | — | 1 | 5.75 |
| CHEMBL573849 | — | — | 1 | 5.46 |
| CHEMBL584774 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573809 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL573717 | — | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL573888 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL573887 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL573845 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL573789 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL573868 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL573849 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL584774 | — | EC50 | > | 10000.0 | nM | - |