Assay Detail
Binding
CHEMBL1037167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.08 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126617 | — | — | 1 | 5.72 |
| CHEMBL487914 | — | — | 1 | 5.64 |
| CHEMBL9941 | — | — | 1 | 5.29 |
| CHEMBL568934 | — | — | 1 | 5.23 |
| CHEMBL571412 | — | — | 1 | 5.10 |
| CHEMBL570096 | — | — | 1 | 5.09 |
| CHEMBL32353 | — | — | 1 | 5.05 |
| CHEMBL576129 | — | — | 1 | 5.04 |
| CHEMBL227701 | — | — | 1 | 4.94 |
| CHEMBL570753 | — | — | 1 | 4.91 |
| CHEMBL571200 | — | — | 1 | 4.83 |
| CHEMBL570095 | — | — | 1 | 4.81 |
| CHEMBL570972 | — | — | 1 | 4.77 |
| CHEMBL227779 | — | — | 1 | 4.71 |
| CHEMBL571085 | — | — | 1 | - |
| CHEMBL572289 | — | — | 1 | - |
| CHEMBL104255 | FLAVOKAWAIN B | — | 1 | - |
| CHEMBL243829 | FLAVOKAWAIN A | — | 1 | - |
| CHEMBL7747 | 4-HYDROXYCHALCONE | — | 1 | - |
| CHEMBL571313 | — | — | 1 | - |
| CHEMBL571956 | — | — | 1 | - |
| CHEMBL145495 | — | — | 1 | - |
| CHEMBL571201 | — | — | 1 | - |
| CHEMBL128000 | BUTEIN | — | 1 | - |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | - |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | — | 1 | - |
| CHEMBL571877 | — | — | 1 | - |
| CHEMBL7976 | CHALCONE | — | 1 | - |
| CHEMBL576131 | — | — | 1 | - |
| CHEMBL450678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126617 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL487914 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL9941 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL568934 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL571412 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL570096 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL32353 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL576129 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL227701 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL570753 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL571200 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL570095 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL570972 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL227779 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL571087 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL570248 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL397256 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL572323 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL571085 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL572289 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL104255 | FLAVOKAWAIN B | IC50 | > | 20000.0 | nM | - |
| CHEMBL243829 | FLAVOKAWAIN A | IC50 | > | 20000.0 | nM | - |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | > | 20000.0 | nM | - |
| CHEMBL571313 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL571956 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL145495 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL571201 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL128000 | BUTEIN | IC50 | > | 20000.0 | nM | - |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | > | 20000.0 | nM | - |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | IC50 | > | 20000.0 | nM | - |
| CHEMBL571877 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL7976 | CHALCONE | IC50 | > | 20000.0 | nM | - |
| CHEMBL576131 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL450678 | — | IC50 | > | 20000.0 | nM | - |