Assay Detail
Binding
CHEMBL1037264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of SAENTA-fluorescein from human ENT1 in HL60 cells by flow cytometry
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Equilibrative nucleoside transporter 1 (CHEMBL1997) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Towards to hENT1-nucleoside transporter selective imaging agents. Synthesis and in vitro evaluation of the radiolabeled SAENTA analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.57 | 8.85 |
| Ki | 2 | 10.47 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571939 | — | — | 2 | 10.74 |
| CHEMBL569223 | — | — | 2 | 10.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571939 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL569223 | — | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL571939 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL569223 | — | IC50 | = | 5.1 | nM | 8.29 |