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Assay Detail

CHEMBL1037323

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat liver FBPase 1
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Fructose-1,6-bisphosphatase 1 (CHEMBL4391)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics.
Dang Q, Kasibhatla SR, Xiao W, Liu Y, Dare J, Taplin F, Reddy KR, Scarlato GR, Gibson T, van Poelje PD, Potter SC, Erion MD.
J Med Chem (2010) 53 : 441 -451
PubMed 20055427 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 45 5.46 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL571017 1 6.46
CHEMBL570326 1 6.40
CHEMBL571207 1 6.35
CHEMBL571872 1 6.30
CHEMBL570790 1 6.26
CHEMBL572055 1 6.19
CHEMBL585946 1 6.07
CHEMBL571018 1 6.05
CHEMBL570089 1 6.05
CHEMBL571426 1 5.89
CHEMBL585915 1 5.80
CHEMBL571839 1 5.70
CHEMBL571879 1 5.70
CHEMBL571844 1 5.70
CHEMBL570965 1 5.70
CHEMBL578624 1 5.70
CHEMBL583139 1 5.70
CHEMBL583346 1 5.70
CHEMBL576291 1 5.70
CHEMBL572202 1 5.70
CHEMBL570796 1 5.70
CHEMBL571183 1 5.70
CHEMBL585541 1 5.70
CHEMBL572062 1 5.70
CHEMBL571654 1 5.68
CHEMBL577117 1 5.68
CHEMBL578622 1 5.66
CHEMBL585945 1 5.64
CHEMBL571840 1 5.60
CHEMBL571182 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL571017 IC50 = 350.0 nM 6.46
CHEMBL570326 IC50 = 400.0 nM 6.40
CHEMBL571207 IC50 = 450.0 nM 6.35
CHEMBL571872 IC50 = 500.0 nM 6.30
CHEMBL570790 IC50 = 550.0 nM 6.26
CHEMBL572055 IC50 = 650.0 nM 6.19
CHEMBL585946 IC50 = 850.0 nM 6.07
CHEMBL570089 IC50 = 900.0 nM 6.05
CHEMBL571018 IC50 = 900.0 nM 6.05
CHEMBL571426 IC50 = 1300.0 nM 5.89
CHEMBL585915 IC50 = 1600.0 nM 5.80
CHEMBL571879 IC50 = 2000.0 nM 5.70
CHEMBL571839 IC50 = 2000.0 nM 5.70
CHEMBL571844 IC50 = 2000.0 nM 5.70
CHEMBL570965 IC50 = 2000.0 nM 5.70
CHEMBL583139 IC50 = 2000.0 nM 5.70
CHEMBL583346 IC50 = 2000.0 nM 5.70
CHEMBL572202 IC50 = 2000.0 nM 5.70
CHEMBL578624 IC50 = 2000.0 nM 5.70
CHEMBL570796 IC50 = 2000.0 nM 5.70
CHEMBL571183 IC50 = 2000.0 nM 5.70
CHEMBL585541 IC50 = 2000.0 nM 5.70
CHEMBL572062 IC50 = 2000.0 nM 5.70
CHEMBL576291 IC50 = 2000.0 nM 5.70
CHEMBL571654 IC50 = 2100.0 nM 5.68
CHEMBL577117 IC50 = 2090.0 nM 5.68
CHEMBL578622 IC50 = 2180.0 nM 5.66
CHEMBL585945 IC50 = 2280.0 nM 5.64
CHEMBL571840 IC50 = 2500.0 nM 5.60
CHEMBL571182 IC50 = 4000.0 nM 5.40
CHEMBL577114 IC50 = 20000.0 nM 4.70
CHEMBL583908 IC50 = 20000.0 nM 4.70
CHEMBL572295 IC50 = 20000.0 nM 4.70
CHEMBL570991 IC50 = 20000.0 nM 4.70
CHEMBL583038 IC50 = 20000.0 nM 4.70
CHEMBL585727 IC50 = 20000.0 nM 4.70
CHEMBL570325 IC50 = 20000.0 nM 4.70
CHEMBL571847 IC50 = 20000.0 nM 4.70
CHEMBL572057 IC50 = 20000.0 nM 4.70
CHEMBL585947 IC50 = 20000.0 nM 4.70
CHEMBL584749 IC50 = 20000.0 nM 4.70
CHEMBL570964 IC50 = 20000.0 nM 4.70
CHEMBL571435 IC50 = 20000.0 nM 4.70
CHEMBL576128 IC50 = 20000.0 nM 4.70
CHEMBL576114 IC50 = 40000.0 nM 4.40