Assay Detail
Functional
CHEMBL1037599
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Antileishmanial activity against Leishmania donovani MHOM/ET/ 67/HU3 amastigote infected in CD1 mouse peritoneal exudate macrophages assessed as parasite growth inhibition after 5 days by Giemsa staining
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.22 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630 | — | — | 1 | 5.85 |
| CHEMBL575071 | — | — | 1 | 5.74 |
| CHEMBL577389 | — | — | 1 | 5.73 |
| CHEMBL573295 | — | — | 1 | 5.69 |
| CHEMBL584808 | — | — | 1 | 5.64 |
| CHEMBL572461 | — | — | 1 | 5.54 |
| CHEMBL575728 | — | — | 1 | 5.33 |
| CHEMBL573053 | — | — | 1 | 5.29 |
| CHEMBL575523 | — | — | 1 | 5.25 |
| CHEMBL576926 | — | — | 1 | 5.17 |
| CHEMBL572594 | — | — | 1 | 5.15 |
| CHEMBL572595 | — | — | 1 | 5.14 |
| CHEMBL572593 | — | — | 1 | 5.06 |
| CHEMBL584771 | — | — | 1 | 5.04 |
| CHEMBL576964 | — | — | 1 | 5.01 |
| CHEMBL573754 | — | — | 1 | 4.93 |
| CHEMBL573296 | — | — | 1 | 4.89 |
| CHEMBL575525 | — | — | 1 | 4.84 |
| CHEMBL573984 | — | — | 1 | 4.83 |
| CHEMBL573506 | — | — | 1 | 4.82 |
| CHEMBL575286 | — | — | 1 | 4.75 |
| CHEMBL2079699 | — | — | 1 | - |
| CHEMBL575909 | — | — | 1 | - |
| CHEMBL575910 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL575071 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL577389 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL573295 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL584808 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL572461 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL575728 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL573053 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL575523 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL576926 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL572594 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL572595 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL572593 | — | IC50 | = | 8770.0 | nM | 5.06 |
| CHEMBL584771 | — | IC50 | = | 9140.0 | nM | 5.04 |
| CHEMBL576964 | — | IC50 | = | 9680.0 | nM | 5.01 |
| CHEMBL573754 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL573296 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL575525 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL573984 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL573506 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL575286 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL2079699 | — | IC50 | = | 188000.0 | nM | - |
| CHEMBL575909 | — | IC50 | > | 89000.0 | nM | - |
| CHEMBL575910 | — | IC50 | > | 83500.0 | nM | - |