Compound Detail
CHEMBL575909
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Basic Information
| ChEMBL ID | CHEMBL575909 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZBDDMZUZJFFUHF-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
300.8
MW (Da)
3.83
ALogP
4
HBA
3
HBD
65.4
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 6.15 | 6.0 | 712.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 712.0 | nM | 6.15 | Antimalarial activity against chloroquine-susceptible Plasmodium falciparum 3D7 ... | 19811859 |
| Plasmodium falciparum | IC50 | = | 1420.0 | nM | 5.85 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 ass... | 19811859 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19811859 | 10.1016/j.ejmech.2009.09.012 | Plasmodium falciparum | 2 |
| 19811859 | 10.1016/j.ejmech.2009.09.012 | Leishmania donovani | 1 |
| 19811859 | 10.1016/j.ejmech.2009.09.012 | KB | 1 |
Data from ChEMBL 36 via Core Engine