Assay Detail
Functional
CHEMBL1037602
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth after 48 hrs by [3H]hypoxanthine reuptake assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.19 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575286 | — | — | 1 | 9.38 |
| CHEMBL576926 | — | — | 1 | 8.85 |
| CHEMBL577389 | — | — | 1 | 8.81 |
| CHEMBL576964 | — | — | 1 | 8.74 |
| CHEMBL572593 | — | — | 1 | 8.67 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.61 |
| CHEMBL575523 | — | — | 1 | 8.26 |
| CHEMBL573295 | — | — | 1 | 8.19 |
| CHEMBL573984 | — | — | 1 | 8.15 |
| CHEMBL1630 | — | — | 1 | 8.06 |
| CHEMBL572461 | — | — | 1 | 8.00 |
| CHEMBL572595 | — | — | 1 | 7.98 |
| CHEMBL584808 | — | — | 1 | 6.65 |
| CHEMBL575071 | — | — | 1 | 6.62 |
| CHEMBL572594 | — | — | 1 | 6.54 |
| CHEMBL575525 | — | — | 1 | 6.41 |
| CHEMBL575910 | — | — | 1 | 6.25 |
| CHEMBL575909 | — | — | 1 | 5.85 |
| CHEMBL573296 | — | — | 1 | 5.83 |
| CHEMBL573754 | — | — | 1 | 4.92 |
| CHEMBL573506 | — | — | 1 | 4.85 |
| CHEMBL573053 | — | — | 1 | 4.85 |
| CHEMBL575728 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575286 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL576926 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL577389 | — | IC50 | = | 1.54 | nM | 8.81 |
| CHEMBL576964 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL572593 | — | IC50 | = | 2.12 | nM | 8.67 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 2.46 | nM | 8.61 |
| CHEMBL575523 | — | IC50 | = | 5.47 | nM | 8.26 |
| CHEMBL573295 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL573984 | — | IC50 | = | 7.04 | nM | 8.15 |
| CHEMBL1630 | — | IC50 | = | 8.61 | nM | 8.06 |
| CHEMBL572461 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL572595 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL584808 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL575071 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL572594 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL575525 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL575910 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL575909 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL573296 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL573754 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL573506 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL573053 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL575728 | — | IC50 | = | 14300.0 | nM | 4.84 |