Assay Detail
Functional
CHEMBL1037601
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Antimalarial activity against chloroquine-susceptible Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 48 hrs by [3H]hypoxanthine reuptake assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.06 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576926 | — | — | 1 | 9.49 |
| CHEMBL575286 | — | — | 1 | 9.17 |
| CHEMBL573295 | — | — | 1 | 8.79 |
| CHEMBL575525 | — | — | 1 | 8.78 |
| CHEMBL1630 | — | — | 1 | 8.67 |
| CHEMBL572593 | — | — | 1 | 8.67 |
| CHEMBL584771 | — | — | 1 | 8.65 |
| CHEMBL577389 | — | — | 1 | 8.51 |
| CHEMBL572595 | — | — | 1 | 8.46 |
| CHEMBL576964 | — | — | 1 | 8.45 |
| CHEMBL573984 | — | — | 1 | 8.28 |
| CHEMBL575523 | — | — | 1 | 8.26 |
| CHEMBL572461 | — | — | 1 | 8.17 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.11 |
| CHEMBL575071 | — | — | 1 | 8.09 |
| CHEMBL573053 | — | — | 1 | 7.91 |
| CHEMBL573296 | — | — | 1 | 7.84 |
| CHEMBL584808 | — | — | 1 | 7.73 |
| CHEMBL575728 | — | — | 1 | 7.65 |
| CHEMBL573506 | — | — | 1 | 7.33 |
| CHEMBL572594 | — | — | 1 | 7.32 |
| CHEMBL573754 | — | — | 1 | 6.90 |
| CHEMBL575910 | — | — | 1 | 6.16 |
| CHEMBL575909 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576926 | — | IC50 | = | 0.323 | nM | 9.49 |
| CHEMBL575286 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL573295 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL575525 | — | IC50 | = | 1.68 | nM | 8.78 |
| CHEMBL1630 | — | IC50 | = | 2.15 | nM | 8.67 |
| CHEMBL572593 | — | IC50 | = | 2.12 | nM | 8.67 |
| CHEMBL584771 | — | IC50 | = | 2.22 | nM | 8.65 |
| CHEMBL577389 | — | IC50 | = | 3.08 | nM | 8.51 |
| CHEMBL572595 | — | IC50 | = | 3.48 | nM | 8.46 |
| CHEMBL576964 | — | IC50 | = | 3.52 | nM | 8.45 |
| CHEMBL573984 | — | IC50 | = | 5.28 | nM | 8.28 |
| CHEMBL575523 | — | IC50 | = | 5.47 | nM | 8.26 |
| CHEMBL572461 | — | IC50 | = | 6.73 | nM | 8.17 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 7.75 | nM | 8.11 |
| CHEMBL575071 | — | IC50 | = | 8.22 | nM | 8.09 |
| CHEMBL573053 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL573296 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL584808 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL575728 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL573506 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL572594 | — | IC50 | = | 48.4 | nM | 7.32 |
| CHEMBL573754 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL575910 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL575909 | — | IC50 | = | 712.0 | nM | 6.15 |