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Assay Detail

CHEMBL1037674

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Functional
Anticancer activity against human HeLa cells after 48 hrs by MTT assay
27
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling.
Zhang L, Jiang H, Cao X, Zhao H, Wang F, Cui Y, Jiang B.
Eur J Med Chem (2009) 44 : 3961 -3972
PubMed 19447525 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.63 5.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL575456 2 5.06
CHEMBL575179 2 4.97
CHEMBL575196 2 4.94
CHEMBL574976 2 4.87
CHEMBL551288 APOGOSSYPOL 2 4.85
CHEMBL574956 2 4.83
CHEMBL575446 2 4.77
CHEMBL51483 GOSSYPOL 3.0 2 4.75
CHEMBL575828 GOSSYPOLONE 1 4.63
CHEMBL575587 2 4.40
CHEMBL575480 2 4.31
CHEMBL575588 2 4.16
CHEMBL575507 2 -
CHEMBL575589 (-)-GOSSYPOL HEXAMETHYL ETHER 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL575456 IC50 = 8700.0 nM 5.06
CHEMBL575179 IC50 = 10700.0 nM 4.97
CHEMBL575196 IC50 = 11400.0 nM 4.94
CHEMBL575179 IC50 = 12500.0 nM 4.90
CHEMBL574976 IC50 = 13500.0 nM 4.87
CHEMBL551288 APOGOSSYPOL IC50 = 14100.0 nM 4.85
CHEMBL574956 IC50 = 14700.0 nM 4.83
CHEMBL575446 IC50 = 17100.0 nM 4.77
CHEMBL51483 GOSSYPOL IC50 = 17800.0 nM 4.75
CHEMBL575456 IC50 = 19600.0 nM 4.71
CHEMBL575196 IC50 = 21800.0 nM 4.66
CHEMBL575828 GOSSYPOLONE IC50 = 23300.0 nM 4.63
CHEMBL575446 IC50 = 23800.0 nM 4.62
CHEMBL551288 APOGOSSYPOL IC50 = 25500.0 nM 4.59
CHEMBL574956 IC50 = 26500.0 nM 4.58
CHEMBL51483 GOSSYPOL IC50 = 31300.0 nM 4.50
CHEMBL575587 IC50 = 39900.0 nM 4.40
CHEMBL575480 IC50 = 49200.0 nM 4.31
CHEMBL575587 IC50 = 51800.0 nM 4.29
CHEMBL574976 IC50 = 55900.0 nM 4.25
CHEMBL575588 IC50 = 69000.0 nM 4.16
CHEMBL575480 IC50 = 73700.0 nM 4.13
CHEMBL575507 IC50 > 80000.0 nM -
CHEMBL575507 IC50 > 80000.0 nM -
CHEMBL575588 IC50 > 80000.0 nM -
CHEMBL575589 (-)-GOSSYPOL HEXAMETHYL ETHER IC50 > 80000.0 nM -
CHEMBL575589 (-)-GOSSYPOL HEXAMETHYL ETHER IC50 > 80000.0 nM -