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Compound Detail

CHEMBL575456

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Cc1cc2c(c(O)c1-c1c(C)cc3c(c1O)/C(=C/N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(=O)C(O)=C3C(C)C)/C(=C/N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(=O)C(O)=C2C(C)C

Basic Information

ChEMBL ID CHEMBL575456
Phase Preclinical
Structure Type MOL
InChI Key FVNKIYDSILCLGI-BDXXZCQXSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

906.9
MW (Da)
6.26
ALogP
16
HBA
10
HBD
306.3
PSA (Ų)
0.04
QED
4
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C48H50N4O14
MW 906.94
Aromatic Rings 4
Heavy Atoms 66
NP-Likeness 0.24

Activity Summary

IC50 5 meas. best 5.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HeLa
CHEMBL399
IC50 5.06 4.885 8700.0 2
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.88 4.7033 13300.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19447525 10.1016/j.ejmech.2009.04.025 Unchecked 8
19447525 10.1016/j.ejmech.2009.04.025 HeLa 6
19447525 10.1016/j.ejmech.2009.04.025 NON-PROTEIN TARGET 4

Data from ChEMBL 36 via Core Engine