Assay Detail
Binding
CHEMBL1037720
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Inhibition of FTase
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3D-QSAR with the aid of pharmacophore search and docking-based alignments for farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 8.59 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440564 | — | — | 1 | 9.82 |
| CHEMBL186617 | — | — | 1 | 9.49 |
| CHEMBL186906 | — | — | 1 | 9.43 |
| CHEMBL187807 | — | — | 1 | 9.43 |
| CHEMBL187128 | — | — | 1 | 9.42 |
| CHEMBL184330 | — | — | 1 | 9.36 |
| CHEMBL181748 | — | — | 1 | 9.31 |
| CHEMBL380554 | — | — | 1 | 9.24 |
| CHEMBL183953 | — | — | 1 | 9.24 |
| CHEMBL182171 | — | — | 1 | 9.22 |
| CHEMBL186927 | — | — | 1 | 9.21 |
| CHEMBL362881 | — | — | 1 | 9.19 |
| CHEMBL363041 | — | — | 1 | 9.09 |
| CHEMBL184916 | — | — | 1 | 9.05 |
| CHEMBL184537 | — | — | 1 | 9.04 |
| CHEMBL181442 | — | — | 1 | 9.02 |
| CHEMBL184568 | — | — | 1 | 8.90 |
| CHEMBL365289 | — | — | 1 | 8.89 |
| CHEMBL362519 | — | — | 1 | 8.89 |
| CHEMBL362750 | — | — | 1 | 8.85 |
| CHEMBL186715 | — | — | 1 | 8.82 |
| CHEMBL362338 | — | — | 1 | 8.77 |
| CHEMBL365362 | — | — | 1 | 8.68 |
| CHEMBL365427 | — | — | 1 | 8.66 |
| CHEMBL185058 | — | — | 1 | 8.52 |
| CHEMBL184425 | — | — | 1 | 8.52 |
| CHEMBL194041 | — | — | 1 | 8.42 |
| CHEMBL182816 | — | — | 1 | 8.40 |
| CHEMBL182810 | — | — | 1 | 8.37 |
| CHEMBL188127 | — | — | 1 | 8.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440564 | — | IC50 | = | 0.1514 | nM | 9.82 |
| CHEMBL186617 | — | IC50 | = | 0.3236 | nM | 9.49 |
| CHEMBL187807 | — | IC50 | = | 0.3715 | nM | 9.43 |
| CHEMBL186906 | — | IC50 | = | 0.3715 | nM | 9.43 |
| CHEMBL187128 | — | IC50 | = | 0.3802 | nM | 9.42 |
| CHEMBL184330 | — | IC50 | = | 0.4365 | nM | 9.36 |
| CHEMBL181748 | — | IC50 | = | 0.4898 | nM | 9.31 |
| CHEMBL380554 | — | IC50 | = | 0.5754 | nM | 9.24 |
| CHEMBL183953 | — | IC50 | = | 0.5754 | nM | 9.24 |
| CHEMBL182171 | — | IC50 | = | 0.6026 | nM | 9.22 |
| CHEMBL186927 | — | IC50 | = | 0.6166 | nM | 9.21 |
| CHEMBL362881 | — | IC50 | = | 0.6457 | nM | 9.19 |
| CHEMBL363041 | — | IC50 | = | 0.8128 | nM | 9.09 |
| CHEMBL184916 | — | IC50 | = | 0.8913 | nM | 9.05 |
| CHEMBL184537 | — | IC50 | = | 0.912 | nM | 9.04 |
| CHEMBL181442 | — | IC50 | = | 0.955 | nM | 9.02 |
| CHEMBL184568 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL365289 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL362519 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL362750 | — | IC50 | = | 1.413 | nM | 8.85 |
| CHEMBL186715 | — | IC50 | = | 1.514 | nM | 8.82 |
| CHEMBL362338 | — | IC50 | = | 1.698 | nM | 8.77 |
| CHEMBL365362 | — | IC50 | = | 2.089 | nM | 8.68 |
| CHEMBL365427 | — | IC50 | = | 2.188 | nM | 8.66 |
| CHEMBL185058 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL184425 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL194041 | — | IC50 | = | 3.802 | nM | 8.42 |
| CHEMBL182816 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL182810 | — | IC50 | = | 4.266 | nM | 8.37 |
| CHEMBL188127 | — | IC50 | = | 4.266 | nM | 8.37 |
| CHEMBL185416 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL187037 | — | IC50 | = | 4.677 | nM | 8.33 |
| CHEMBL186641 | — | IC50 | = | 4.786 | nM | 8.32 |
| CHEMBL193340 | — | IC50 | = | 6.166 | nM | 8.21 |
| CHEMBL184044 | — | IC50 | = | 6.457 | nM | 8.19 |
| CHEMBL363524 | — | IC50 | = | 6.761 | nM | 8.17 |
| CHEMBL185053 | — | IC50 | = | 7.586 | nM | 8.12 |
| CHEMBL183313 | — | IC50 | = | 8.318 | nM | 8.08 |
| CHEMBL187254 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL434146 | — | IC50 | = | 12.88 | nM | 7.89 |
| CHEMBL194172 | — | IC50 | = | 28.84 | nM | 7.54 |
| CHEMBL371818 | — | IC50 | = | 46.77 | nM | 7.33 |
| CHEMBL195553 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL187244 | — | IC50 | = | 95.5 | nM | 7.02 |
| CHEMBL363751 | — | IC50 | = | 346.74 | nM | 6.46 |