Compound Detail
CHEMBL363751
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N#Cc1ccc(COCc2cncn2Cc2ccc(C#N)cc2-c2ccc3c(c2)OCO3)c(-c2ccc3c(c2)OCO3)c1
Basic Information
| ChEMBL ID | CHEMBL363751 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GQYPRGGNCKGHIV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
568.6
MW (Da)
6.18
ALogP
9
HBA
0
HBD
111.5
PSA (Ų)
0.22
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 6.47 | 6.47 | 340.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.46 | 6.46 | 346.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 340.0 | nM | 6.47 | Inhibition of bovine farnesyltransferase | 15454229 |
| Unchecked | IC50 | = | 346.74 | nM | 6.46 | Inhibition of FTase | 19515462 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15454229 | 10.1016/j.bmcl.2004.08.011 | Protein farnesyltransferase | 2 |
| 15454229 | 10.1016/j.bmcl.2004.08.011 | Geranylgeranyl transferase type I | 1 |
| 19515462 | 10.1016/j.ejmech.2009.04.045 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine