Assay Detail
Binding
CHEMBL831678
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Inhibition of bovine farnesyltransferase
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 8.70 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186617 | — | — | 1 | 9.49 |
| CHEMBL187807 | — | — | 1 | 9.43 |
| CHEMBL186906 | — | — | 1 | 9.43 |
| CHEMBL187128 | — | — | 1 | 9.42 |
| CHEMBL184330 | — | — | 1 | 9.36 |
| CHEMBL181748 | — | — | 1 | 9.31 |
| CHEMBL183953 | — | — | 1 | 9.24 |
| CHEMBL182171 | — | — | 1 | 9.22 |
| CHEMBL186927 | — | — | 1 | 9.21 |
| CHEMBL362881 | — | — | 1 | 9.19 |
| CHEMBL184044 | — | — | 1 | 9.19 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 9.19 |
| CHEMBL363041 | — | — | 1 | 9.09 |
| CHEMBL184916 | — | — | 1 | 9.05 |
| CHEMBL184537 | — | — | 1 | 9.04 |
| CHEMBL181442 | — | — | 1 | 9.02 |
| CHEMBL184568 | — | — | 1 | 8.92 |
| CHEMBL362519 | — | — | 1 | 8.89 |
| CHEMBL365289 | — | — | 1 | 8.89 |
| CHEMBL362750 | — | — | 1 | 8.85 |
| CHEMBL186715 | — | — | 1 | 8.82 |
| CHEMBL362338 | — | — | 1 | 8.77 |
| CHEMBL365427 | — | — | 1 | 8.66 |
| CHEMBL185058 | — | — | 1 | 8.52 |
| CHEMBL184425 | — | — | 1 | 8.52 |
| CHEMBL182816 | — | — | 1 | 8.40 |
| CHEMBL188127 | — | — | 1 | 8.37 |
| CHEMBL182810 | — | — | 1 | 8.37 |
| CHEMBL185416 | — | — | 1 | 8.36 |
| CHEMBL187037 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186617 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL187807 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL186906 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL187128 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL184330 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL181748 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL183953 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL182171 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL186927 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL184044 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL362881 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL363041 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL184916 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL184537 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL181442 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL184568 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL362519 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL365289 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL362750 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL186715 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL362338 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL365427 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL185058 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL184425 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL182816 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL188127 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL182810 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL185416 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL187037 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL186641 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL363524 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL185053 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL183313 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL187254 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL434146 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL187244 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL363751 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL181649 | — | IC50 | > | 10000.0 | nM | - |