Assay Detail
Functional
CHEMBL1037776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 pNL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.94 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.80 |
| CHEMBL575512 | — | — | 1 | 7.77 |
| CHEMBL584342 | — | — | 1 | 7.60 |
| CHEMBL584969 | — | — | 1 | 7.32 |
| CHEMBL574652 | — | — | 1 | 7.27 |
| CHEMBL300891 | — | — | 1 | 7.22 |
| CHEMBL584763 | — | — | 1 | 6.99 |
| CHEMBL575276 | — | — | 1 | 6.91 |
| CHEMBL577569 | — | — | 1 | 6.85 |
| CHEMBL584761 | — | — | 1 | 6.79 |
| CHEMBL576364 | — | — | 1 | 6.62 |
| CHEMBL573747 | — | — | 1 | 6.55 |
| CHEMBL573061 | — | — | 1 | 6.54 |
| CHEMBL466535 | — | — | 1 | 6.35 |
| CHEMBL575717 | — | — | 1 | 6.25 |
| CHEMBL575916 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL575512 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL584342 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL584969 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL574652 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL300891 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL584763 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL575276 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL577569 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL584761 | — | EC50 | = | 162.0 | nM | 6.79 |
| CHEMBL576364 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL573747 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL573061 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL466535 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL575717 | — | EC50 | = | 558.0 | nM | 6.25 |
| CHEMBL575916 | — | EC50 | = | 620.0 | nM | 6.21 |