Assay Detail
Functional
CHEMBL1037779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay in presence of 50% human serum
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.16 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575276 | — | — | 1 | 6.82 |
| CHEMBL584969 | — | — | 1 | 6.62 |
| CHEMBL584763 | — | — | 1 | 6.60 |
| CHEMBL574652 | — | — | 1 | 6.55 |
| CHEMBL574873 | — | — | 1 | 6.36 |
| CHEMBL584764 | — | — | 1 | 6.25 |
| CHEMBL573747 | — | — | 1 | 6.22 |
| CHEMBL584765 | — | — | 1 | 6.19 |
| CHEMBL466535 | — | — | 1 | 5.82 |
| CHEMBL575916 | — | — | 1 | 5.72 |
| CHEMBL573215 | — | — | 1 | 5.41 |
| CHEMBL282457 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575276 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL584969 | — | EC50 | = | 241.0 | nM | 6.62 |
| CHEMBL584763 | — | EC50 | = | 249.0 | nM | 6.60 |
| CHEMBL574652 | — | EC50 | = | 284.0 | nM | 6.55 |
| CHEMBL574873 | — | EC50 | = | 433.0 | nM | 6.36 |
| CHEMBL584764 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL573747 | — | EC50 | = | 601.0 | nM | 6.22 |
| CHEMBL584765 | — | EC50 | = | 648.0 | nM | 6.19 |
| CHEMBL466535 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL575916 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL573215 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL282457 | — | EC50 | = | 4500.0 | nM | 5.35 |