Assay Detail
Functional
CHEMBL1037784
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Antiviral activity against indinavir-resistant HIV1 harboring L10R/M46I/L63P/V82T/I84V mutant protease infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.22 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300891 | — | — | 1 | 7.00 |
| CHEMBL584761 | — | — | 1 | 6.81 |
| CHEMBL584342 | — | — | 1 | 6.80 |
| CHEMBL577569 | — | — | 1 | 6.76 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 6.42 |
| CHEMBL575276 | — | — | 1 | 6.39 |
| CHEMBL584969 | — | — | 1 | 6.38 |
| CHEMBL574652 | — | — | 1 | 6.33 |
| CHEMBL584763 | — | — | 1 | 6.25 |
| CHEMBL466535 | — | — | 1 | 5.85 |
| CHEMBL576364 | — | — | 1 | 5.76 |
| CHEMBL575717 | — | — | 1 | 5.71 |
| CHEMBL573747 | — | — | 1 | 5.69 |
| CHEMBL573061 | — | — | 1 | 5.66 |
| CHEMBL575916 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300891 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL584761 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL584342 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL577569 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL575276 | — | EC50 | = | 409.0 | nM | 6.39 |
| CHEMBL584969 | — | EC50 | = | 416.0 | nM | 6.38 |
| CHEMBL574652 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL584763 | — | EC50 | = | 568.0 | nM | 6.25 |
| CHEMBL466535 | — | EC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL576364 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL575717 | — | EC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL573747 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL573061 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL575916 | — | EC50 | = | 3010.0 | nM | 5.52 |