Assay Detail
Functional
CHEMBL1038009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced increase in intracellular cAMP level by cAMP-LANCE method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.88 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL605405 | — | — | 1 | 7.06 |
| CHEMBL592752 | MARITUPIRDINE | 2.0 | 1 | 6.80 |
| CHEMBL592271 | — | — | 1 | 6.75 |
| CHEMBL605081 | — | — | 1 | 6.56 |
| CHEMBL591569 | — | — | 1 | 6.26 |
| CHEMBL589147 | — | — | 1 | 6.18 |
| CHEMBL589148 | — | — | 1 | 6.16 |
| CHEMBL601902 | — | — | 1 | 6.04 |
| CHEMBL589388 | — | — | 1 | 6.01 |
| CHEMBL592753 | — | — | 1 | 6.01 |
| CHEMBL591570 | — | — | 1 | 6.00 |
| CHEMBL589389 | — | — | 1 | 5.98 |
| CHEMBL589149 | — | — | 1 | 5.95 |
| CHEMBL589390 | LATREPIRDINE | 3.0 | 1 | 5.94 |
| CHEMBL589386 | — | — | 1 | 5.84 |
| CHEMBL592516 | — | — | 1 | 5.82 |
| CHEMBL601304 | — | — | 1 | 5.78 |
| CHEMBL591801 | — | — | 1 | 5.76 |
| CHEMBL604669 | — | — | 1 | 5.70 |
| CHEMBL603049 | — | — | 1 | 5.64 |
| CHEMBL589150 | — | — | 1 | 5.63 |
| CHEMBL591568 | — | — | 1 | 5.59 |
| CHEMBL592514 | — | — | 1 | 5.55 |
| CHEMBL604668 | — | — | 1 | 5.53 |
| CHEMBL592751 | — | — | 1 | 5.43 |
| CHEMBL606036 | — | — | 1 | 5.39 |
| CHEMBL592515 | — | — | 1 | 5.25 |
| CHEMBL599913 | — | — | 1 | 5.24 |
| CHEMBL591803 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL605405 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL592752 | MARITUPIRDINE | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL592271 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL605081 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL591569 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL589147 | — | IC50 | = | 666.0 | nM | 6.18 |
| CHEMBL589148 | — | IC50 | = | 692.0 | nM | 6.16 |
| CHEMBL601902 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL589388 | — | IC50 | = | 974.0 | nM | 6.01 |
| CHEMBL592753 | — | IC50 | = | 977.0 | nM | 6.01 |
| CHEMBL591570 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL589389 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL589149 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL589390 | LATREPIRDINE | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL589386 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL592516 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL601304 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL591801 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL604669 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL603049 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL589150 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL591568 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL592514 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL604668 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL592751 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL606036 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL592515 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL599913 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL591803 | — | IC50 | = | 20700.0 | nM | 4.68 |