Assay Detail
Functional
CHEMBL1038041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus replication after 4 days by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 6.33 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 8.40 |
| CHEMBL585013 | — | — | 1 | 8.40 |
| CHEMBL477121 | — | — | 1 | 8.05 |
| CHEMBL565514 | — | — | 1 | 8.00 |
| CHEMBL569254 | — | — | 1 | 7.89 |
| CHEMBL569989 | — | — | 1 | 7.40 |
| CHEMBL566386 | — | — | 1 | 7.37 |
| CHEMBL569489 | — | — | 1 | 7.20 |
| CHEMBL569990 | — | — | 1 | 6.98 |
| CHEMBL565319 | — | — | 1 | 6.66 |
| CHEMBL565318 | — | — | 1 | 6.38 |
| CHEMBL569991 | — | — | 1 | 6.37 |
| CHEMBL569289 | — | — | 1 | 6.31 |
| CHEMBL478168 | — | — | 1 | 6.31 |
| CHEMBL565512 | — | — | 1 | 6.14 |
| CHEMBL583243 | — | — | 1 | 6.04 |
| CHEMBL569318 | — | — | 1 | 5.91 |
| CHEMBL584756 | — | — | 1 | 5.91 |
| CHEMBL567013 | — | — | 1 | 5.74 |
| CHEMBL569253 | — | — | 1 | 5.72 |
| CHEMBL568867 | — | — | 1 | 5.66 |
| CHEMBL584283 | — | — | 1 | 5.34 |
| CHEMBL583834 | — | — | 1 | 5.07 |
| CHEMBL567238 | — | — | 1 | 5.00 |
| CHEMBL578392 | — | — | 1 | 4.95 |
| CHEMBL583861 | — | — | 1 | 4.92 |
| CHEMBL567044 | — | — | 1 | 4.85 |
| CHEMBL565326 | — | — | 1 | 4.31 |
| CHEMBL577951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL585013 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL477121 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL565514 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL569254 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL569989 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL566386 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL569489 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL569990 | — | EC50 | = | 104.0 | nM | 6.98 |
| CHEMBL565319 | — | EC50 | = | 217.0 | nM | 6.66 |
| CHEMBL565318 | — | EC50 | = | 416.0 | nM | 6.38 |
| CHEMBL569991 | — | EC50 | = | 426.0 | nM | 6.37 |
| CHEMBL569289 | — | EC50 | = | 485.0 | nM | 6.31 |
| CHEMBL478168 | — | EC50 | = | 491.0 | nM | 6.31 |
| CHEMBL565512 | — | EC50 | = | 717.0 | nM | 6.14 |
| CHEMBL583243 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL569318 | — | EC50 | = | 1239.0 | nM | 5.91 |
| CHEMBL584756 | — | EC50 | = | 1245.0 | nM | 5.91 |
| CHEMBL567013 | — | EC50 | = | 1825.0 | nM | 5.74 |
| CHEMBL569253 | — | EC50 | = | 1895.0 | nM | 5.72 |
| CHEMBL568867 | — | EC50 | = | 2185.0 | nM | 5.66 |
| CHEMBL584283 | — | EC50 | = | 4561.0 | nM | 5.34 |
| CHEMBL583834 | — | EC50 | = | 8470.0 | nM | 5.07 |
| CHEMBL567238 | — | EC50 | = | 9977.0 | nM | 5.00 |
| CHEMBL578392 | — | EC50 | = | 11131.0 | nM | 4.95 |
| CHEMBL583861 | — | EC50 | = | 11878.0 | nM | 4.92 |
| CHEMBL567044 | — | EC50 | = | 14106.0 | nM | 4.85 |
| CHEMBL565326 | — | EC50 | = | 49135.0 | nM | 4.31 |
| CHEMBL577951 | — | EC50 | = | 126401.0 | nM | - |