Assay Detail
Functional
CHEMBL1038048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV with reverse transcriptase CNDO mutant assessed as inhibition of viral replication
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.02 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.30 |
| CHEMBL491019 | — | — | 1 | 8.96 |
| CHEMBL572324 | — | — | 1 | 8.96 |
| CHEMBL489586 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL491019 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL572324 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL489586 | — | IC50 | = | 1.4 | nM | 8.85 |