Assay Detail
Binding
CHEMBL1038131
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Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.09 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL568138 | — | — | 1 | 8.52 |
| CHEMBL566685 | — | — | 1 | 8.52 |
| CHEMBL566242 | — | — | 1 | 8.15 |
| CHEMBL565843 | — | — | 1 | 8.15 |
| CHEMBL566875 | — | — | 1 | 7.85 |
| CHEMBL496102 | AMG-208 | 2.0 | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL568138 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL566685 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL566242 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL565843 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL566875 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL496102 | AMG-208 | IC50 | = | 46.0 | nM | 7.34 |