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Assay Detail

CHEMBL1038643

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HL60 cells by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Phytochemical investigation of labdane diterpenes from the rhizomes of Hedychium spicatum and their cytotoxic activity.
Reddy PP, Rao RR, Shashidhar J, Sastry BS, Rao JM, Babu KS.
Bioorg Med Chem Lett (2009) 19 : 6078 -6081
PubMed 19782567 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.63 5.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL44657 ETOPOSIDE 4.0 1 5.67
CHEMBL582854 1 4.80
CHEMBL95956 4-METHOXY ETHYL CINNAMATE 1 4.53
CHEMBL109252 CORONARIN E 1 4.51
CHEMBL117 CHRYSIN 1 4.47
CHEMBL318196 ETHYL CINNAMATE 1 4.45
CHEMBL511204 YUNNACORONARIN D 1 4.44
CHEMBL573722 SPICATANOIC ACID 1 4.16
CHEMBL507971 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL44657 ETOPOSIDE IC50 = 2160.0 nM 5.67
CHEMBL582854 IC50 = 15950.0 nM 4.80
CHEMBL95956 4-METHOXY ETHYL CINNAMATE IC50 = 29640.0 nM 4.53
CHEMBL109252 CORONARIN E IC50 = 31210.0 nM 4.51
CHEMBL117 CHRYSIN IC50 = 33980.0 nM 4.47
CHEMBL318196 ETHYL CINNAMATE IC50 = 35690.0 nM 4.45
CHEMBL511204 YUNNACORONARIN D IC50 = 36430.0 nM 4.44
CHEMBL573722 SPICATANOIC ACID IC50 = 69390.0 nM 4.16
CHEMBL507971 IC50 - -