Assay Detail
Binding
CHEMBL1038744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8OH-DPAT from 5HT1A in Sprague-Dawley rat brain cortex by liquid scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.18 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 9.10 |
| CHEMBL568284 | — | — | 1 | 7.85 |
| CHEMBL566331 | — | — | 1 | 7.45 |
| CHEMBL566533 | — | — | 1 | 7.41 |
| CHEMBL583422 | — | — | 1 | 5.00 |
| CHEMBL565707 | — | — | 1 | 5.00 |
| CHEMBL568285 | — | — | 1 | 5.00 |
| CHEMBL586050 | — | — | 1 | 5.00 |
| CHEMBL567834 | — | — | 1 | 5.00 |
| CHEMBL567648 | — | — | 1 | 5.00 |
| CHEMBL584919 | — | — | 1 | - |
| CHEMBL567649 | — | — | 1 | - |
| CHEMBL565484 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL568284 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL566331 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL566533 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL583422 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL565707 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL568285 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL586050 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL567834 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL567648 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL584919 | — | Ki | - | — | - | |
| CHEMBL567649 | — | Ki | - | — | - | |
| CHEMBL565484 | — | Ki | - | — | - |