Assay Detail
Binding
CHEMBL1038852
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Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.59 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201170 | — | — | 1 | 9.41 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 8.23 |
| CHEMBL380330 | — | — | 1 | 7.54 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 7.45 |
| CHEMBL593897 | — | — | 1 | 6.87 |
| CHEMBL596448 | — | — | 1 | 6.74 |
| CHEMBL594789 | — | — | 1 | 5.90 |
| CHEMBL593394 | — | — | 1 | 5.76 |
| CHEMBL596179 | — | — | 1 | 5.68 |
| CHEMBL593395 | — | — | 1 | 5.67 |
| CHEMBL594127 | — | — | 1 | 5.63 |
| CHEMBL594798 | — | — | 1 | 5.52 |
| CHEMBL610449 | — | — | 2 | 5.32 |
| CHEMBL595720 | — | — | 1 | - |
| CHEMBL594799 | — | — | 1 | - |
| CHEMBL594557 | — | — | 1 | - |
| CHEMBL593626 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201170 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL380330 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 35.7 | nM | 7.45 |
| CHEMBL593897 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL596448 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL594789 | — | Ki | = | 1264.0 | nM | 5.90 |
| CHEMBL593394 | — | Ki | = | 1727.0 | nM | 5.76 |
| CHEMBL596179 | — | Ki | = | 2070.0 | nM | 5.68 |
| CHEMBL593395 | — | Ki | = | 2116.0 | nM | 5.67 |
| CHEMBL594127 | — | Ki | = | 2349.0 | nM | 5.63 |
| CHEMBL594798 | — | Ki | = | 3019.0 | nM | 5.52 |
| CHEMBL610449 | — | Ki | = | 4748.0 | nM | 5.32 |
| CHEMBL594557 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL595720 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL610449 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL594799 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL593626 | — | Ki | > | 10000.0 | nM | - |