Assay Detail
Binding
CHEMBL1038899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRbeta in human SF539 cells by phosphotyrosine ELISA
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SF-539 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.83 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 5.62 |
| CHEMBL610181 | — | — | 1 | 4.89 |
| CHEMBL594339 | — | — | 1 | 4.76 |
| CHEMBL595497 | — | — | 1 | 4.05 |
| CHEMBL595757 | — | — | 1 | - |
| CHEMBL606039 | — | — | 1 | - |
| CHEMBL594810 | — | — | 1 | - |
| CHEMBL594320 | — | — | 1 | - |
| CHEMBL604879 | — | — | 1 | - |
| CHEMBL593154 | — | — | 1 | - |
| CHEMBL603849 | — | — | 1 | - |
| CHEMBL605413 | — | — | 1 | - |
| CHEMBL603198 | — | — | 1 | - |
| CHEMBL594790 | — | — | 1 | - |
| CHEMBL606362 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276711 | SEMAXANIB | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL610181 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL594339 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL595497 | — | IC50 | = | 88200.0 | nM | 4.05 |
| CHEMBL595757 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL606039 | — | IC50 | = | 151900.0 | nM | - |
| CHEMBL594810 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL594320 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL604879 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL593154 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL603849 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL605413 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL603198 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL594790 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL606362 | — | IC50 | > | 200000.0 | nM | - |